Indian believers swallow live fish to cure asthma

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Bushnell HD Torch ? Now Even Flashlights Have Gone HD

I love flashlights and?sometimes spend hours looking at?them on various retail web?sites. But you have to admit, other than size, style and lumens, there really isn’t THAT much of a difference from one torch to another. That’s why I was really excited when I stumbled upon the Bushnell HD Torch during a surfing session. I’d [...]

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95% Moonrise Kingdom

All Critics (133) | Top Critics (39) | Fresh (126) | Rotten (6) | DVD (1)

The latest unadulterated delight from Wes Anderson, director of "Rushmore," "The Royal Tenenbaums" and "Fantastic Mr. Fox."

The usual complaints and caveats about Anderson - he's precious, his characters have no grounding in the real world - can be made about Moonrise Kingdom, but so what?

Anderson and his actors are able to convey more genuine feeling through these devices than most filmmakers can with more-traditional means.

One knock against some of Anderson's previous efforts is that they're too clever - so clever, in fact, that the humanity gets sucked out of them. That doesn't happen here.

Anderson's best feature since Rushmore, in part because, like that film, it takes as its primary subject matter odd, precocious children, rather than the damaged and dissatisfied adults they will one day become.

There's no denying the extravagant pleasures "Moonrise Kingdom" affords as an erudite wish-fulfillment fantasy of empowerment and autonomy.

It's sweet, charming, quirky, imaginative, poignant, and whimsical. Just what a Wes Anderson film should be.

Anderson has trouble sticking the landing, but "Moonrise Kingdom" is in many ways the most satisfying flight he's taken us on in years.

"Moonrise Kingdom" takes place in a world where everything seems pleasantly faded, where people read crackly-covered library books rather than e-books, and where young people are allowed to be genuinely innocent.

A remarkable story, stopping to survey the author's superlative descriptions and attention to the tiniest fragments of heartbreak. It's a treat to watch unfold, sweetened gorgeously by Anderson's magical manner of thinking.

I loved every second of "Moonrise Kingdom."

Thoroughly well scripted and well-acted. May be the greatest work to date from one of the greatest directors working.

Moonrise Kingdom?s heartfelt search and rescue of a feel-good result provides a perfect, even musical counterpoint to its regimented summer camp.

This is a Wes Anderson film. It's gonna be quaint. It's gonna be wry. It's gonna look just like Anderson's other features. But is that such a bad thing?

A marvelously funny, wry script

Despite the star power on display here, the movie is not for everyone

Wes Anderson's best work in a decade, as he returns to the nimble territory precariously balanced between fairy-tale whimsy and genuine emotion

More Critic Reviews

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Clergy group begins campaign against marriage amendment (Star Tribune)

Share With Friends: | | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

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The real culprit behind hardened arteries? Stem cells, says landmark study

ScienceDaily (June 6, 2012) ? One of the top suspects behind killer vascular diseases is the victim of mistaken identity, according to researchers from the University of California, Berkeley, who used genetic tracing to help hunt down the real culprit.

The guilty party is not the smooth muscle cells within blood vessel walls, which for decades was thought to combine with cholesterol and fat that can clog arteries. Blocked vessels can eventually lead to heart attacks and strokes, which account for one in three deaths in the United States.

Instead, a previously unknown type of stem cell -- a multipotent vascular stem cell -- is to blame, and it should now be the focus in the search for new treatments, the scientists report in a new study appearing June 6 in the journal Nature Communications.

"For the first time, we are showing evidence that vascular diseases are actually a kind of stem cell disease," said principal investigator Song Li, professor of bioengineering and a researcher at the Berkeley Stem Cell Center. "This work should revolutionize therapies for vascular diseases because we now know that stem cells rather than smooth muscle cells are the correct therapeutic target."

The finding that a stem cell population contributes to artery-hardening diseases, such as atherosclerosis, provides a promising new direction for future research, the study authors said.

"This is groundbreaking and provocative work, as it challenges existing dogma," said Dr. Deepak Srivastava, who directs cardiovascular and stem cell research at the Gladstone Institutes in San Francisco, and who provided some of the mouse vascular tissues used by the researchers. "Targeting the vascular stem cells rather than the existing smooth muscle in the vessel wall might be much more effective in treating vascular disease."

It is generally accepted that the buildup of artery-blocking plaque stems from the body's immune response to vessel damage caused by low-density lipoproteins, the bad cholesterol many people try to eliminate from their diets. Such damage attracts legions of white blood cells and can spur the formation of fibrous scar tissue that accumulates within the vessel, narrowing the blood flow.

The scar tissue, known as neointima, has certain characteristics of smooth muscle, the dominant type of tissue in the blood vessel wall. Because mature smooth muscle cells no longer multiply and grow, it was theorized that in the course of the inflammatory response, they revert, or de-differentiate, into an earlier state where they can proliferate and form matrices that contribute to plaque buildup.

However, no experiments published have directly demonstrated this de-differentiation process, so Li and his research team remained skeptical. They turned to transgenic mice with a gene that caused their mature smooth muscle cells to glow green under a microscope.

In analyzing the cells from cross sections of the blood vessels, they found that more than 90 percent of the cells in the blood vessels were mature smooth muscle cells. They then isolated and cultured the cells taken from the middle layer of the mouse blood vessels.

After one month of cell expansion, the researchers saw a threefold increase in the size of the cell nucleus and the spreading area, along with an increase in stress fibers. Notably, none of the new, proliferating cells glowed green, which meant that their lineage could not be traced back to the mature smooth muscle cells originally isolated from the blood vessels.

"Not only was there a lack of green markers in the cell cultures, but we noticed that another type of cell isolated from the blood vessels exhibited progenitor traits for different types of tissue, not just smooth muscle cells," said Zhenyu Tang, co-lead author of the study and a Ph.D. student in the UC Berkeley-UCSF Graduate Program in Bioengineering.

The other co-lead author of the study, Aijun Wang, was a post-doctoral researcher in Li's lab.

"The different phenotypes gave us the clue that stem cells were involved," said Wang, who is now an assistant professor and the co-director of the Surgical Bioengineering Laboratory at the UC Davis Medical Center. "We did further tests and detected proteins and transcriptional factors that are only found in stem cells. No one knew that these cells existed in the blood vessel walls because no one looked for them before."

Further experiments determined that the newly discovered vascular stem cells were multipotent, or capable of differentiating into various specialized cell types, including smooth muscle, nerve, cartilage, bone and fat cells. This would explain why previous studies misidentified the cells involved in vessel clogs as de-differentiated smooth muscle cells after vascular injury.

"In the later stages of vascular disease, the soft vessels become hardened and more brittle," said Li. "Previously, there was controversy about how soft tissue would become hard. The ability of stem cells to form bone or cartilage could explain this calcification of the blood vessels."

Other tests in the study showed that the multipotent stem cells were dormant under normal physiological conditions. When the blood vessel walls were damaged, the stem cells rather than the mature smooth muscle cells became activated and started to multiply.

The researchers analyzed human carotid arteries to confirm that the same type of multipotent vascular stem cells are found in human blood vessels.

"If your target is wrong, then your treatment can't be very effective," said Dr. Shu Chien, director of the Institute of Engineering in Medicine at UC San Diego, and Li's former adviser. "These new findings give us the right target and should speed up the discovery of novel treatments for vascular diseases."

Grants from the National Institutes of Health and the California Institute for Regenerative Medicine helped support this research.

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Story Source:

The above story is reprinted from materials provided by University of California - Berkeley. The original article was written by Sarah Yang.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Zhenyu Tang, Aijun Wang, Falei Yuan, Zhiqiang Yan, Bo Liu, Julia S. Chu, Jill A. Helms, Song Li. Differentiation of multipotent vascular stem cells contributes to vascular diseases. Nature Communications, 2012; 3: 875 DOI: 10.1038/ncomms1867

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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French and English Tuition in London with an Experienced Tutor

June 3rd, 2012

I am a tutor of French and English as a foreign language. I did a degree in French and then a PGCE in order to teach French in secondary schools. I taught at a school for one year but realised that I preferred teaching privately on a one-to-one basis. I taught languages in France in 2007, using my French skills to teach high school pupils with my own lesson plans and materials. I taught English for St Giles in Oxford in 2010, teaching students of mixed nationality. Since moving back to London I have found students through an agency called?French tuition London. I have also tutored pupils preparing for their French GCSE. Lessons are planned around the needs of the learner, whether preparing for exams or learning for fun. My approach is interactive; I guide the learner through exercises and explanations, and encourage them to find answers and solutions for themselves. Lessons are always focussed on an aspect of language

Entry Filed under: Reference and Education

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Sexual tension simmers in many male-female friendships ? Chicago ...

We all know about ?friends with benefits,? but is there such a thing as friends with no benefits?

A recent study from the University of Wisconsin-Eau Claire suggests not. Researchers surveyed more than 400 individuals from the ages of 18-52 and asked them questions about their friendships with the opposite sex. Their findings were surprising: A large number of survey respondents admitted they felt some level of attraction for their friends.

Researchers also found an interesting gender disparity in their results. Not only were men more likely to report feelings of attraction, but they also were more likely to believe that their female friends reciprocated those feelings. On the other hand, women were more likely to underestimate their male friends? feelings of attraction.

These differing gender results point to one of the main reasons why male-female friendships are so complicated. One friend might believe that the relationship is purely platonic while the other has hidden feelings of desire, or one friend might hope that the relationship is going to blossom into something more while the other has no intention of ever taking it to that level.

If you are in a relationship, this issue becomes even more complicated. The researchers found that the higher the level of attraction between a person and their friend, the lower the level of satisfaction that person would feel with their significant other. This could be because the relationship already was unsatisfactory so the person sought other ways to fulfill their emotional needs, or it could mean that friendship itself had a destabilizing effect on the relationship. Either way, the friend has now become a roadblock in the relationship.

Even if the affair never becomes physical, an emotional affair can be equally devastating and hurtful to your relationship. You are devoting time, energy and love to your friend instead of your mate, and that can easily harm your bond and lead to feelings of jealousy. No wonder relationship dissatisfaction grows in situations such as these.

Of course, this doesn?t mean that men and women can never be friends. Yet it is risky to assume that male-female friendships aren?t different than same-sex friendships. We are inherently sexual creatures and most of us cannot simply turn off feelings of attraction with a simple switch. Our sexuality is much more complicated than that, and even the happiest of relationships can be harmed by an overly intimate friendship.

Luckily, there are a few things you can do to help safeguard your bond. First, make sure your partner is OK with your friendship and be sure to include him in some of your outings with your pal. If you feel the need to hide the friendship or keep the two of them separate, that could be a red flag.

Second, don?t put yourself in situations where disaster might occur. Don?t go back to your pal?s apartment for a nightcap while the rest of your friends head home, and don?t overindulge in alcohol or other activities that might lower your inhibitions.

Third, keep an eye out for signs that he or she might have the wrong idea about your relationship, and keep your conversations free of sexual innuendo and flirtation. One good way to ensure that the relationship stays platonic is to ask yourself: Would I be embarrassed if my partner saw my behavior right now? Would I be angry if my significant other was behaving this way with a friend of the opposite sex?

Lastly, make sure that you aren?t spending more time and effort on the friendship than you are on the relationship. Your partner deserves the bulk of your time, energy and love, and if you spend that outside the relationship, you won?t be able to give that to him. Remember, men and women can be friends, but it can be risky, so unless you can keep yourself honest, straightforward and absolutely platonic at all times (and be ascertained that your friend can too), it can be a dangerous path.

Dr. Berman is the star of ?In The Bedroom with Dr. Laura Berman? on OWN and director of drlauraberman.com.

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